NCK2 monoclonal antibody, clone AF3F11
产品名称： NCK2 monoclonal antibody, clone AF3F11
英文名称： NCK2 monoclonal antibody, clone AF3F11
产品编号： MAB2727
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against recombinant NCK2.
- Immunogen:
- Recombinant His fusion protein corresponding to human NCK2.
- Host:
- Mouse
- Reactivity:
- Human, Rat
- Form:
- Liquid
- Purification:
- Ammonium sulfate precipitation
- Concentration:
- 1 mg/mL
- Storage Buffer:
- In HEPES, 150 mM NaCl (50% glycerol, 0.01% BSA, 0.03% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1:2000)
Immunoprecipitation (1 ul)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stress.
Latreille M, Larose L.J Biol Chem. 2006 Sep 8;281(36):26633-44. Epub 2006 Jul 11.
- 2.
- The phosphotyrosine peptide binding specificity of Nck1 and Nck2 Src homology 2 domains.
Frese S, Schubert WD, Findeis AC, Marquardt T, Roske YS, Stradal TE, Heinz DW.J Biol Chem. 2006 Jun 30;281(26):18236-45. Epub 2006 Apr 24.
- 3.
- The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network.
Bladt F, Aippersbach E, Gelkop S, Strasser GA, Nash P, Tafuri A, Gertler FB, Pawson T.Mol Cell Biol. 2003 Jul;23(13):4586-97.
- Entrez GeneID:
- 8440
- Gene Name:
- NCK2
- Gene Alias:
- GRB4,NCKbeta
- Gene Description:
- NCK adaptor protein 2
- Omim ID:
- 604930
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
- Other Designations:
- SH2/SH3 adaptor protein NCK-beta,noncatalytic region of tyrosine kinase, beta
- Related Disease