EDNRB polyclonal antibody
产品名称： EDNRB polyclonal antibody
英文名称： EDNRB polyclonal antibody
产品编号： PAB7971
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of EDNRB.
- Immunogen:
- A synthetic peptide corresponding to amino acids at middle region region of human EDNRB.
- Host:
- Rabbit
- Theoretical MW (kDa):
- 49.6
- Reactivity:
- Human
- Specificity:
- The sequence identical to the related rat sequence.
- Form:
- Lyophilized
- Purification:
- Affinity purification
- Storage Buffer:
- Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)
- Storage Instruction:
- Store at -20°C on dry atmosphere.
After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide and thimerosal: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- The temporal requirement for endothelin receptor-B signalling during neural crest development.
Shin MK, Levorse JM, Ingram RS, Tilghman SM.Nature. 1999 Dec 2;402(6761):496-501.
- 2.
- A dinucleotide mutation in the endothelin-B receptor gene is associated with lethal white foal syndrome (LWFS); a horse variant of Hirschsprung disease.
Yang GC, Croaker D, Zhang AL, Manglick P, Cartmill T, Cass D.Hum Mol Genet. 1998 Jun;7(6):1047-52.
- 3.
- Null mutation of endothelin receptor type B gene in spotting lethal rats causes aganglionic megacolon and white coat color.
Gariepy CE, Cass DT, Yanagisawa M.Proc Natl Acad Sci U S A. 1996 Jan 23;93(2):867-72.
- Entrez GeneID:
- 1910
- Gene Name:
- EDNRB
- Gene Alias:
- ABCDS,ETB,ETBR,ETRB,HSCR,HSCR2
- Gene Description:
- endothelin receptor type B
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Three transcript variants encoding two different isoforms have been found for this gene. While both isoforms bind ET1, they exhibit different responses upon binding, suggesting that they may be functionally distinct. [provided by RefSeq
- Other Designations:
- OTTHUMP00000178736,endothelin receptor non-selective type
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