TP53 (phospho S37) polyclonal antibody
产品名称: TP53 (phospho S37) polyclonal antibody
英文名称: TP53 (phospho S37) polyclonal antibody
产品编号: PAB16954
产品价格: null
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围:
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of TP53.
- Immunogen:
- Synthetic phosphopeptide corresponding to residues surrounding S37 of human TP53.
- Host:
- Rabbit
- Reactivity:
- Human
- Specificity:
- This antibody detects endogenous levels of TP53 only when phosphorylated at serine 37.
- Form:
- Liquid
- Storage Buffer:
- In 20 mM PBS, 0.15 M NaCl, pH 7.2 (0.01% sodium azide)
- Storage Instruction:
- Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
ELISA (1:4000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- An ATM- and Rad3-related (ATR) signaling pathway and a phosphorylation-acetylation cascade are involved in activation of p53/p21Waf1/Cip1 in response to 5-aza-2'-deoxycytidine treatment.
Wang H, Zhao Y, Li L, McNutt MA, Wu L, Lu S, Yu Y, Zhou W, Feng J, Chai G, Yang Y, Zhu WG.J Biol Chem. 2008 Feb 1;283(5):2564-74. Epub 2007 Oct 31.
- 2.
- Phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified.
Mayo LD, Seo YR, Jackson MW, Smith ML, Rivera Guzman J, Korgaonkar CK, Donner DB.J Biol Chem. 2005 Jul 15;280(28):25953-9. Epub 2005 Apr 20.
- 3.
- Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis.
Thompson T, Tovar C, Yang H, Carvajal D, Vu BT, Xu Q, Wahl GM, Heimbrook DC, Vassilev LT.J Biol Chem. 2004 Dec 17;279(51):53015-22. Epub 2004 Oct 6.
- Application Image
- Western Blot
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- enlarge
- ELISA
- Entrez GeneID:
- 7157
- Protein Accession#:
- P04637
- Gene Name:
- TP53
- Gene Alias:
- FLJ92943,LFS1,TRP53,p53
- Gene Description:
- tumor protein p53
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity. [provided by RefSeq
- Other Designations:
- p53 antigen,p53 transformation suppressor,p53 tumor suppressor,phosphoprotein p53,transformation-related protein 53
- Interactome
- Gene Pathway
- Amyotrophic lateral sclerosis (ALS)
- Apoptosis
- Basal cell carcinoma
- Bladder cancer
- Cell cycle
- Chronic myeloid leukemia
- Colorectal cancer
- Endometrial cancer
- Glioma
- Huntington's disease
- MAPK signaling pathway
- Melanoma
- Neurotrophin signaling pathway
- Non-small cell lung cancer
- p53 signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Prostate cancer
- Small cell lung cancer
- Thyroid cancer
- Wnt signaling pathway
- Related Disease
- Abortion, Habitual
- Abortion, Spontaneous
- Acquired Hyperostosis Syndrome
- Acute Disease
- Adenocarcinoma
- Adenocarcinoma, Clear Cell
- Adenocarcinoma, Follicular
- Adenocarcinoma, Mucinous
- Adenoma
- Adenoma, Liver Cell
- Adenomatous Polyposis Coli
- Adrenal Cortex Neoplasms
- Albuminuria
- Alcoholism
- Alzheimer Disease
- Alzheimer disease
- Ameloblastoma
- Aneuploidy
- Anoxia