FITC标记的G蛋白偶联受体26抗体
产品名称： FITC标记的G蛋白偶联受体26抗体
英文名称： Anti-GPR26/FITC
产品编号： HZ-13527R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-GPR26/FITC Conjugated antibody
FITC标记的G蛋白偶联受体26抗体
| 英文名称 | Anti-GPR26/FITC |
| 中文名称 | FITC标记的G蛋白偶联受体26抗体 |
| 别 名 | AXOR49; DKFZp761H2121; FLJ33774; G protein-coupled receptor 26; G protein-coupled receptor 26; G protein-coupled receptor GPR26; MGC138216; GPR26_HUMAN; GPCR GPR26. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 G蛋白偶联受体 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 38kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human G protein-coupled receptor 26 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: G protein-coupled receptors (GPRs) are a protein family of transmembrane receptors that transmit an extracellular signal (ligand binding) into an intracellular signal (G protein activation). GPR signaling is an ancient evolutionarily mechanism used by all eukaryotes to sense environmental stimuli and mediate cell-cell communication. GPRs have seven membrane-spanning domains and the extracellular domains are often glycosylated. These extracellular loops also contain two highly conserved cysteine residues which create disulfide bonds to stabilize the receptor structure. GPR26 (G-protein coupled receptor 26) is a 337 amino acid protein that is primarily expressed in regions of the brain. GPR26 is characterized as an ‘orphan’ G protein-coupled receptor, which is a receptor that binds an unidentified natural ligand. Due to evidence of GPR26 being downregulated in glioblastomas, it has been suggested that GPR26 may be a suppressor of early glioma development. Function: GPCR GPR26 is an Orphan receptor. It displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. Is highly expressed in the CNS, the highest expression is seen in the amygdala, hippocampus and thalamus. Weak expression is detected in testis. Down-regulated in glioblastoma. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Highly expressed in the CNS, the highest expression is seen in the amygdala, hippocampus and thalamus. Weak expression is detected in testis. Down-regulated in glioblastoma. Similarity: Belongs to the G-protein coupled receptor 1 family. Database links: Entrez Gene: 2849 Human Entrez Gene: 233919 Mouse Entrez Gene: 192153 Rat Omim: 604847 Human SwissProt: Q8NDV2 Human SwissProt: Q8BZA7 Mouse SwissProt: Q9QXI3 Rat Unigene: 12751 Human Unigene: 208740 Mouse Unigene: 48779 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
G蛋白偶联受体(GPR)是跨膜受体的蛋白家族，将细胞外信号(配体结合)传递到细胞内信号(G蛋白激活)。GPR信号传导是所有真核生物用来感知环境刺激并介导细胞间通讯的一种古老的进化机制。GPRS有七个跨膜结构域，胞外结构域通常是糖基化的。这些细胞外环还含有两个高度保守的半胱氨酸残基，它们产生二硫键以稳定受体结构。GPR26（G蛋白偶联受体26）是一种主要在脑区表达的337氨基酸蛋白。GPR26的特征是“孤儿”G蛋白偶联受体，它是一种结合未知天然配体的受体。由于有证据表明GPR26在胶质母细胞瘤中下调，因此GPR26可能是早期胶质瘤发展的抑制剂。