MAP3K11 polyclonal antibody
产品名称： MAP3K11 polyclonal antibody
英文名称： MAP3K11 polyclonal antibody
产品编号： PAB2108
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of MAP3K11.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to internal region of human MAP3K11.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein A purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:50-100)
Immunohistochemistry (1:50)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Oncogenic kinase signalling.
Blume-Jensen P, Hunter T.Nature. 2001 May 17;411(6835):355-65.
- 2.
- Phosphoinositide 3-kinase signalling pathways.
Cantrell DA.J Cell Sci. 2001 Apr;114(Pt 8):1439-45.
- 3.
- The RET proto-oncogene in human cancers.
Jhiang SM.Oncogene. 2000 Nov 20;19(49):5590-7.
- Applications
- Western Blot (Transfected lysate)
- Western blot analysis of MAP3K11 (arrow) using MAP3K11 polyclonal antibody (Cat # PAB2108). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MAP3K11 gene (Lane 2) (Origene Technologies).
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with MAP3K11 polyclonal antibody (Cat # PAB2108) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated.
- Entrez GeneID:
- 4296
- Protein Accession#:
- NP_002410;Q16584
- Gene Name:
- MAP3K11
- Gene Alias:
- MGC17114,MLK-3,MLK3,PTK1,SPRK
- Gene Description:
- mitogen-activated protein kinase kinase kinase 11
- Omim ID:
- 600050
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq
- Other Designations:
- SH3 domain-containing proline-rich kinase,mixed lineage kinase 3,protein-tyrosine kinase PTK1
- Gene Pathway