<p><p><p> <strong><span style="font-family: 微软雅黑;font-size: 19px"><span style="font-family:微软雅黑">产品简介</span></span></strong><strong></strong> </p> <p> <span style=";font-family:微软雅黑;color:rgb(35,31,32);font-size:16px"><span style="font-family:微软雅黑">活体颅骨光透明试剂盒是在武汉光电国家</span> 实验室长期对活体光透明技术研究的基础上研发的一款<strong>活体光透明试剂盒</strong>，能够在实验动物活体状态下进行颅骨透明化。试 剂盒操作简单快捷、</span><span style="font-size: 16px;">非侵入实现大小鼠大脑皮层神经网络、血管网络及血流流速的观察与监测，有利于研究其大脑深部皮层神经网络和血管结构与功能。</span> </p> <p> <span style="font-family: 微软雅黑;font-size: 16px"> </span> </p> <p> <strong><span style="font-family: 微软雅黑;font-size: 19px"><span style="font-family:微软雅黑">技术特点</span></span></strong><strong></strong> </p> <p> <strong><span style="font-family: 微软雅黑;font-size: 16px"> </span></strong> </p> <p> <strong><span style="font-family: 微软雅黑;font-size: 16px"><span style="font-family:微软雅黑">1.无损、非侵入颅窗透明：</span></span></strong><strong><span style="font-family: 微软雅黑;font-size: 19px"> </span></strong><strong></strong> </p> <p> <span style=";font-family:微软雅黑;font-size:16px"><span style="font-family:微软雅黑">不会损伤皮层或者颅骨，避免传统开颅</span> </span> </p> <p> <span style=";font-family:微软雅黑;font-size:16px"><span style="font-family:微软雅黑">或颅窗手术带来的诸多问题</span> </span> </p> <p> <strong><span style="font-family: 微软雅黑;font-size: 16px"><span style="font-family:微软雅黑">2.大幅度提升成像深度：</span></span></strong><strong><span style="font-family: 微软雅黑;font-size: 19px"> </span></strong> </p> <p> <span style=";font-family:微软雅黑;font-size:16px"><span style="font-family:微软雅黑">使光学成像</span>“看”得更深 </span> </p> <p> <strong><span style="font-family: 微软雅黑;font-size: 16px"><span style="font-family:微软雅黑">3.成像背景十分“清澈”： </span></span></strong> </p> <p> <span style=";font-family:微软雅黑;font-size:16px"><span style="font-family:微软雅黑">提升成像分辨率和成像质量</span> </span> </p> <p> <strong><span style="font-family: 微软雅黑;font-size: 16px"><span style="font-family:微软雅黑">4.操作简单透明速度快： </span></span></strong> </p> <p> <span style=";font-family:微软雅黑;font-size:16px"><span style="font-family:微软雅黑">透明过程仅需</span>20min </span> </p> <p> <strong><span style="font-family: 微软雅黑;font-size: 16px"><span style="font-family:微软雅黑">5.光透明处理可逆，反复成像： </span></span></strong> </p> <p> <span style=";font-family:微软雅黑;font-size:16px"><span style="font-family:微软雅黑">移除透明剂后颅骨可再生，可反复成像</span></span> </p> <p> <br> </p> <p style="text-align: center"> <img style="max-width:800px;max-height:300%;" src="https://img71.chem17.com/9/20220309/637824169458072000778.png" title="28410681.png" alt="28410681.png"> </p> <p> <br> </p> <p> <br> </p> <p> <strong><span style="font-family: 微软雅黑;font-size: 19px"><span style="font-family:微软雅黑">规格</span></span></strong><strong></strong> </p> <p> <strong><span style="font-family: 微软雅黑;font-size: 19px"> </span></strong> </p> <div class="tabledivclass" style="width: 99%; height: 199px;"> <table border="1" cellspacing="0" align="left" style="max-width: 748px;"> <tbody> <tr style="height:35px" class="firstRow"> <td width="67" valign="center" style="padding: 0px 7px; border-width: 1px; border-style: solid; border-color: windowtext;"> <p style=";text-autospace:ideograph-numeric;text-align:center"> <strong><span style="font-family: 微软雅黑;font-size: 16px"><span style="font-family:微软雅黑">规格</span></span></strong><strong></strong> </p> </td> <td width="190" valign="center" style="padding: 0px 7px; border-width: 1px; border-style: solid; border-color: windowtext;"> <p style=";text-autospace:ideograph-numeric;text-align:center"> <strong><span style="font-family: 微软雅黑;font-size: 16px"><span style="font-family:微软雅黑">A液和B液分别规格</span></span></strong><strong></strong> </p> </td> <td width="115" valign="center" style="padding: 0px 7px; border-width: 1px; border-style: solid; border-color: windowtext;"> <p style=";text-autospace:ideograph-numeric;text-align:center"> <strong><span style="font-family: 微软雅黑;font-size: 16px"><span style="font-family:微软雅黑">颅骨透明次数</span></span></strong><strong></strong> </p> </td> <td width="180" valign="center" style="padding: 0px 7px; border-width: 1px; border-style: solid; border-color: windowtext;"> <p style=";text-autospace:ideograph-numeric;text-align:center"> <strong><span style="font-family: 微软雅黑;font-size: 16px"><span style="font-family:微软雅黑">备注</span></span></strong> </p> </td> </tr> <tr style="height:35px"> <td width="67" valign="center" style="padding: 0px 7px; border-left: 1px solid windowtext; border-right: 1px solid windowtext; border-top: none; border-bottom: 1px solid windowtext;"> <p style=";text-autospace:ideograph-numeric;text-align:center"> <span style="font-family: 微软雅黑;font-size: 16px"><span style="font-family:微软雅黑">35ml</span></span> </p> </td> <td width="190" valign="center" style="padding: 0px 7px; border-left: 1px solid windowtext; border-right: 1px solid windowtext; border-top: none; border-bottom: 1px solid windowtext;"> <p style=";text-autospace:ideograph-numeric;text-align:center"> <span style="font-family: 微软雅黑;font-size: 16px"><span style="font-family:微软雅黑">A液20ml B液15ml</span></span> </p> </td> <td width="115" valign="center" style="padding: 0px 7px; border-left: 1px solid windowtext; border-right: 1px solid windowtext; border-top: none; border-bottom: 1px solid windowtext;"> <p style=";text-autospace:ideograph-numeric;text-align:center"> <strong><span style="font-family: 微软雅黑;font-size: 16px"><span style="font-family:微软雅黑">约</span>10-15次</span></strong> </p> </td> <td width="180" valign="center" style="padding: 0px 7px; border-left: 1px solid windowtext; border-right: 1px solid windowtext; border-top: none; border-bottom: 1px solid windowtext;"> <p style=";text-autospace:ideograph-numeric;text-align:center"> <span style="font-family: 微软雅黑;font-size: 16px"><span style="font-family:微软雅黑">自行颅骨透明建议配置透明支架</span></span> </p> </td> </tr> <tr style="height:34px"> <td width="67" valign="center" style="padding: 0px 7px; border-left: 1px solid windowtext; border-right: 1px solid windowtext; border-top: none; border-bottom: 1px solid windowtext;"> <p style=";text-autospace:ideograph-numeric;text-align:center"> <span style="font-family: 微软雅黑;font-size: 16px"><span style="font-family:微软雅黑">80ml</span></span> </p> </td> <td width="190" valign="center" style="padding: 0px 7px; border-left: 1px solid windowtext; border-right: 1px solid windowtext; border-top: none; border-bottom: 1px solid windowtext;"> <p style=";text-autospace:ideograph-numeric;text-align:center"> <span style="font-family: 微软雅黑;font-size: 16px"><span style="font-family:微软雅黑">A液45ml B液35ml</span></span> </p> </td> <td width="115" valign="center" style="padding: 0px 7px; border-left: 1px solid windowtext; border-right: 1px solid windowtext; border-top: none; border-bottom: 1px solid windowtext;"> <p style=";text-autospace:ideograph-numeric;text-align:center"> <strong><span style="font-family: 微软雅黑;font-size: 16px"><span style="font-family:微软雅黑">约</span>20-30次</span></strong> </p> </td> <td width="180" valign="center" style="padding: 0px 7px; border-left: 1px solid windowtext; border-right: 1px solid windowtext; border-top: none; border-bottom: 1px solid windowtext;"> <p style=";text-autospace:ideograph-numeric;text-align:center"> <span style="font-family: 微软雅黑;font-size: 16px"><span style="font-family:微软雅黑">自行颅骨透明建议配置透明支架</span></span> </p> </td> </tr> <tr style="height:33px"> <td width="67" valign="center" style="padding: 0px 7px; border-left: 1px solid windowtext; border-right: 1px solid windowtext; border-top: none; border-bottom: 1px solid windowtext;"> <p style=";text-autospace:ideograph-numeric;text-align:center"> <span style="font-family: 微软雅黑;font-size: 16px"><span style="font-family:微软雅黑">180ml</span></span> </p> </td> <td width="190" valign="center" style="padding: 0px 7px; border-left: 1px solid windowtext; border-right: 1px solid windowtext; border-top: none; border-bottom: 1px solid windowtext;"> <p style=";text-autospace:ideograph-numeric;text-align:center"> <span style="font-family: 微软雅黑;font-size: 16px"><span style="font-family:微软雅黑">A液100ml B液80ml</span></span> </p> </td> <td width="115" valign="center" style="padding: 0px 7px; border-left: 1px solid windowtext; border-right: 1px solid windowtext; border-top: none; border-bottom: 1px solid windowtext;"> <p style=";text-autospace:ideograph-numeric;text-align:center"> <strong><span style="font-family: 微软雅黑;font-size: 16px"><span style="font-family:微软雅黑">约</span>50-80次</span></strong> </p> </td> <td width="180" valign="center" style="padding: 0px 7px; border-left: 1px solid windowtext; border-right: 1px solid windowtext; border-top: none; border-bottom: 1px solid windowtext;"> <p style=";text-autospace:ideograph-numeric;text-align:center"> <span style="font-family: 微软雅黑;font-size: 16px"><span style="font-family:微软雅黑">自行颅骨透明建议配置透明支架</span></span> </p> </td> </tr> </tbody> </table> </div> <p> <span style="font-family: 微软雅黑;font-size: 16px"> </span> </p> <p> <strong><span style="font-family: 微软雅黑;font-size: 19px"><span style="font-family:微软雅黑">应用方向</span></span></strong><strong></strong> </p> <p> <strong><span style="font-family: 微软雅黑;font-size: 19px"> </span></strong> </p> <p> <strong><span style="font-family: 微软雅黑;color: rgb(35, 31, 32);font-size: 16px"><span style="font-family:微软雅黑">双光子成像</span> </span></strong><strong></strong> </p> <p> <span style=";font-family:微软雅黑;color:rgb(35,31,32);font-size:16px"><span style="font-family:微软雅黑">双光子成像</span>(Two-PhotonI ma ging)技术以其优越特性被广泛用于活细胞动态三维成像，该技术使得在体外对生物组织进行三维亚微米尺度的研究成为可能。小鼠颅骨在皮质上阻碍了荧光标记的神经元结构和微血管的观察。活体光透明辅助双光子显微镜，无需颅窗手术“越过”颅骨成像观察。大量的实验结果表明，活体颅骨光透明试剂盒不仅提高了成像分辨率和对比度，而且还改善了成像深度。</span> </p> <p> <br> </p> <p style="text-align: center"> <img src="https://img73.chem17.com/9/20220309/637824170046532549739.jpg" style="max-width:800px;max-height:300%;" title="28410675.jpeg"> </p> <p style=";text-autospace:ideograph-numeric;text-align:center"> <span style=";font-family:微软雅黑;color:rgb(35,31,32);font-size:14px">活体颅骨光透明试剂处理后，在对照区域进行比较双光子成像的观察深度大幅提升</span> </p> <p> <span style=";font-family:微软雅黑;color:rgb(35,31,32);font-size:14px"><br></span> </p> <p> <br> </p> <p style="text-align: center"> <img src="https://img73.chem17.com/9/20220309/637824170069932699248.png" style="max-width: 800px; max-height: 300%; width: 515px; height: 600px;" title="sv.png" width="515" height="600"> </p> <p style=";text-autospace:ideograph-numeric;text-align:center"> <span style=";font-family:微软雅黑;color:rgb(35,31,32);font-size:12px"><span style="font-family:微软雅黑">活体颅骨光透明试剂处理后，在对照区域进行比较，双光子成像的清晰度和观察深度都大大加强</span></span> </p> <p style=";text-autospace:ideograph-numeric;text-align:center"> <span style=";font-family:Calibri;font-size:19px"> </span> </p> <p> <strong><span style="font-family: 微软雅黑;font-size: 16px"><span style="font-family:微软雅黑">激光散斑血流成像</span></span></strong><strong></strong> </p> <p> <span style=";font-family:微软雅黑;color:rgb(35,31,32);font-size:16px"><span style="font-family:微软雅黑">激光散斑血流成像技术受限于成像深度，对皮肤表面的血管和血流能够成像，再深层观察不佳。活体颅骨光透明试剂处理后，不但可以提升激光散斑血流成像深度，而且提升了分辨率。</span></span> </p> <p> <br> </p> <p style="text-align: center"> <img style="max-width: 800px; max-height: 300%; width: 719px; height: 132px;" src="https://img75.chem17.com/9/20220309/637824170714959660207.jpg" title="222.jpg" alt="222.jpg" width="719" height="132"> </p> <p> <span style="color: rgb(35, 31, 32); font-family: 微软雅黑; text-indent: 14px;"> 小鼠脑皮层激光血<span style="text-indent: 42px;">流成像图</span></span><span style="color: rgb(35, 31, 32); font-family: 微软雅黑; text-indent: 14px;"> 颅骨光透明后的</span><span style="color: rgb(35, 31, 32); font-family: 微软雅黑; text-indent: 42px;">血流成像图</span><span style="color: rgb(35, 31, 32); font-family: 微软雅黑; text-indent: 14px;"> 小鼠背部皮窗激</span><span style="color: rgb(35, 31, 32); font-family: 微软雅黑; text-indent: 42px;">光血流成像图 </span><span style="color: rgb(35, 31, 32); font-family: 微软雅黑; text-indent: 14px;"> 颅骨光透明后血</span><span style="color: rgb(35, 31, 32); font-family: 微软雅黑; text-indent: 42px;"> 流成像图</span> </p> <p style="text-indent: 42px;"><br></p></p></p>