FITC标记的白细胞介素-12受体β2抗体
产品名称： FITC标记的白细胞介素-12受体β2抗体
英文名称： Anti-IL12RB2/FITC
产品编号： HZ-2604R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749 点击查看
- 传真 : 点击查看
- 邮箱 : www.shzbio.net
- 二维码 : 点击查看
Rabbit Anti-IL12RB2/FITC Conjugated antibody
FITC标记的白细胞介素-12受体β2抗体
| 英文名称 | Anti-IL12RB2/FITC |
| 中文名称 | FITC标记的白细胞介素-12受体β2抗体 |
| 别 名 | Interleukin-12 receptor subunit beta-2; RP11-102M16.1; IL12 receptor beta 2; IL12R beta2; Interleukin 12 receptor beta 2; Interleukin 12 receptor beta 2 chain; RP11 102M16.1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 95kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IL-12RB2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. [provided by RefSeq]. Function: Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production. Subcellular Location: Membrane; Single pass type I membrane protein. Tissue Specificity: Isoform 2 is expressed at similar levels in both naive and activated T-cells. Post-translational modifications: On IL12 binding, phosphorylated on C-terminal tyrosine residues by JAK2. Phosphorylation on Tyr-800 is required for STAT4 binding and activation, and for SOCS3 binding. Similarity: Belongs to the type I cytokine receptor family. Type 2 subfamily. Contains 5 fibronectin type-III domains. Database links: Entrez Gene: 282452 Cow Entrez Gene: 489550 Dog Entrez Gene: 100722774 Guinea pig Entrez Gene: 3595 Human Entrez Gene: 16162 Mouse Entrez Gene: 397178 Pig Entrez Gene: 100350416 Rabbit Entrez Gene: 171334 Rat Entrez Gene: 100820736 Sheep Omim: 601642 Human SwissProt: Q99665 Human SwissProt: P97378 Mouse Unigene: 479347 Human Unigene: 188337 Mouse Unigene: 207395 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
由该基因编码的蛋白质是I型跨膜蛋白，被鉴定为白细胞介素12受体复合物的亚基。这和IL12RB1蛋白的共表达显示导致高亲和力的IL12结合位点的形成和IL12依赖信号的重建。Th1细胞中γ干扰素上调该基因的表达，在Th1细胞分化中起重要作用。该基因的上调与多种感染性疾病有关，如克罗恩病和麻风病，据认为这有助于炎症反应和宿主防御。[由RefSeq提供]。