HDAC5 polyclonal antibody
产品名称： HDAC5 polyclonal antibody
英文名称： HDAC5 polyclonal antibody
产品编号： PAB2331
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of HDAC5.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human HDAC5.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Direct interaction of Ca2+/calmodulin inhibits histone deacetylase 5 repressor core binding to myocyte enhancer factor 2.
Berger I, Bieniossek C, Schaffitzel C, Hassler M, Santelli E, Richmond TJ.J Biol Chem. 2003 May 16;278(20):17625-35. Epub 2003 Mar 6.
- 2.
- Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation.
Zhang CL, McKinsey TA, Olson EN.Mol Cell Biol. 2002 Oct;22(20):7302-12.
- 3.
- Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor.
Lemercier C, Brocard MP, Puvion-Dutilleul F, Kao HY, Albagli O, Khochbin S.J Biol Chem. 2002 Jun 14;277(24):22045-52. Epub 2002 Apr 19.
- Entrez GeneID:
- 10014
- Protein Accession#:
- Q9UQL6
- Gene Name:
- HDAC5
- Gene Alias:
- FLJ90614,HD5,NY-CO-9
- Gene Description:
- histone deacetylase 5
- Omim ID:
- 605315
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- antigen NY-CO-9