PKM抗体-抗体-抗体-生物在线
上海信裕生物科技有限公司
PKM抗体

PKM抗体

商家询价

产品名称： PKM抗体

英文名称： PKMAntibody

产品编号： XY25659-1

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

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 PKM抗体Applications

Tested Applications: ELISA, WB
Specificity Reaction: Human; Other species are not tested.Please decide the specificity by homology
Positive WB detected in HeLa cells, COLO 320 cells, HEK-293 cells, MCF-7 cells, SMMC-7721 cells
Recommended dilution WB : 1:500-1:5000
 PKM抗体Application key: WB=Western Blotting ,IHC=Immunohistochemistry, IF=Immunofluorescence
Images
Prev1NextView more validation data
  • 25659-1-AP;HeLa cellsHeLa cells were subjected to SDS PAGE followed by western blot with 25659-1-AP( PKM Antibody) at dilution of 1:1000
Product Information PKM抗体
Source: Rabbit Purify: Antigen affinity purification
IsoType: IgG Storage: PBS with 0.1% sodium azide and 50% glycerol pH 7.3. -20oC, Avoid freeze / thaw cycles.
Immunogen Information
Immunogen: PKM fusion protein ag20270 Full Name: PKM2 pyruvate kinase, muscle
Caculated Molecular
Weight:		 58 kDa Observed Molecular 
Weight:		 55 kDa
GenbankNo BC000481 GeneID: 5315
Symbol PKM2 Synonyms CTHBP, OIP 3, OIP3, Opa interacting protein 3, p58, PK2, PK3, PKM, PKM1, PKM2, PKM2 pyruvate kinase, muscle, Pyruvate kinase 2/3, Pyruvate kinase isozymes M1/M2, Pyruvate kinase muscle isozyme, TCB, THBP1, Tumor M2 PK
Background

PKM, also named as OIP3, PK2, PK3, PK-M1/2, p58, THBP1, CTHBP and Tumor M2-PK, belongs to the pyruvate kinase family. It is glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. It stimulates POU5F1-mediated transcriptional activation. PKM plays a general role in caspase independent cell death of tumor cells. The activity of the M2 isoform (but not the M1 isoform) can be inhibited by tyrosine kinase signalling in tumourcells.The primary pyruvate kinase isoform before tumour development is PK-M1; however, the primary isoform from four independent tumours is PK-M2.(PMID:18337823). PKM, Pyruvate kinase isozymes M1/M2, has 2 isoforms . This antibody can recognize both PK-M1 and PK-M2. PKM抗体

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