GRB2 polyclonal antibody
产品名称： GRB2 polyclonal antibody
英文名称： GRB2 polyclonal antibody
产品编号： PAB14689
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of GRB2.
- Immunogen:
- A synthetic peptide corresponding to amino acids 198-217 of human GRB2.
- Host:
- Rabbit
- Theoretical MW (kDa):
- 26
- Reactivity:
- Human
- Specificity:
- This antibody recognizes Grb2, a highly conserved approximately 26 KDa adaptorprotein.
- Form:
- Liquid
- Concentration:
- 1 mg/mL
- Storage Buffer:
- In PBS (0.2% BSA, 15 mM sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1 mg/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Tight association of GRB2 with receptor protein-tyrosine phosphatase alpha is mediated by the SH2 and C-terminal SH3 domains.
den Hertog J, Hunter T.EMBO J. 1996 Jun 17;15(12):3016-27.
- 2.
- GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation.
Sieh M, Batzer A, Schlessinger J, Weiss A.Mol Cell Biol. 1994 Jul;14(7):4435-42.
- 3.
- SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated tyrosine kinases.
Reif K, Buday L, Downward J, Cantrell DA.J Biol Chem. 1994 May 13;269(19):14081-7.
- Entrez GeneID:
- 2885
- Gene Name:
- GRB2
- Gene Alias:
- ASH,EGFRBP-GRB2,Grb3-3,MST084,MSTP084
- Gene Description:
- growth factor receptor-bound protein 2
- Omim ID:
- 108355
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- HT027,OTTHUMP00000166096,OTTHUMP00000166097,OTTHUMP00000166098,abundant SRC homology,epidermal growth factor receptor-binding protein GRB2,growth factor receptor-bound protein 3
- Gene Pathway
- Acute myeloid leukemia
- B cell receptor signaling pathway
- Chemokine signaling pathway
- Chronic myeloid leukemia
- Colorectal cancer
- Dorso-ventral axis formation
- Endometrial cancer
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Focal adhesion
- Gap junction
- Glioma
- GnRH signaling pathway
- Insulin signaling pathway
- Jak-STAT signaling pathway
- MAPK signaling pathway
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Non-small cell lung cancer
- Pathways in cancer
- Prostate cancer
- Renal cell carcinoma
- T cell receptor signaling pathway