FITC标记的非霍奇金淋巴瘤蛋白抗体
产品名称： FITC标记的非霍奇金淋巴瘤蛋白抗体
英文名称： Anti-RTEL1/FITC
产品编号： HZ-18886R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-RTEL1/FITC Conjugated antibody
FITC标记的非霍奇金淋巴瘤蛋白抗体
| 英文名称 | Anti-RTEL1/FITC |
| 中文名称 | FITC标记的非霍奇金淋巴瘤蛋白抗体 |
| 别 名 | bK3184A7.3; C20orf41; Chromosome 20 open reading frame 41; DKCA4; DKCB5; DKFZP434C013; KIAA1088; NHL; Novel helicase like; Regulator of telomere elongation helicase 1; Regulator of telomere length; RP4-583P15.2; RTEL. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Rat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 150kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RTEL1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a DNA helicase which functions in the stability, protection and elongation of telomeres and interacts with proteins in the shelterin complex known to protect telomeres during DNA replication. Mutations in this gene have been associated with dyskeratosis congenita and Hoyerall-Hreidarsson syndrome. Read-through transcription of this gene into the neighboring downstream gene, which encodes tumor necrosis factor receptor superfamily, member 6b, generates a non-coding transcript. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013] Function: ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere. Subunit: Interacts with TERF1. Interacts (via PIP-box) with PCNA; the interaction is direct and essential for suppressing telomere fragility. Interacts with MMS19; the interaction mediates the association of RTEL1 with the cytosolic iron-sulfur protein assembly (CIA) complex. Subcellular Location: Nuclear DISEASE: Dyskeratosis congenita, autosomal recessive, 5 (DKCB5) [MIM:615190]: A form of dyskeratosis congenita, a rare multisystem disorder caused by defective telomere maintenance. It is characterized by progressive bone marrow failure, and the clinical triad of reticulated skin hyperpigmentation, nail dystrophy, and mucosal leukoplakia. Common but variable features include premature graying, aplastic anemia, low platelets, osteoporosis, pulmonary fibrosis, and liver fibrosis among others. Early mortality is often associated with bone marrow failure, infections, fatal pulmonary complications, or malignancy. DKCB5 is characterized by onset of bone marrow failure and immunodeficiency in early childhood. Most patients also have growth and developmental delay and cerebellar hypoplasia, consistent with a clinical diagnosis of Hoyeraal-Hreidarsson syndrome. Similarity: Belongs to the helicase family. RAD3/XPD subfamily. Contains 1 helicase ATP-binding domain. Database links:
Entrez Gene: 51750 Human Entrez Gene: 269400 Mouse Omim: 608833 Human SwissProt: Q9NZ71 Human SwissProt: Q0VGM9 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
这个基因编码一个DNA螺旋酶，它在端粒的稳定性、保护和伸长中起作用，并与已知在DNA复制过程中保护端粒的保护蛋白复合物中的蛋白质相互作用。该基因的突变与先天性角化不良和Hoeer-HurdARsson综合征有关。将该基因读入邻近的下游基因，编码肿瘤坏死因子受体超家族成员6b，产生非编码转录。选择性剪接导致多个转录子变体编码不同的亚型。[ RefSeq，SEP 2013提供]