IRGM polyclonal antibody
产品名称： IRGM polyclonal antibody
英文名称： IRGM polyclonal antibody
产品编号： PAB13357
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of IRGM.
- Immunogen:
- A synthetic peptide corresponding to N-terminus 17 amino acids of human IRGM.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Form:
- Liquid
- Storage Buffer:
- In PBS (0.02% sodium azide)
- Storage Instruction:
- Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.
Fisher SA, Tremelling M, Anderson CA, Gwilliam R, Bumpstead S, Prescott NJ, Nimmo ER, Massey D, Berzuini C, Johnson C, Barrett JC, Cummings FR, Drummond H, Lees CW, Onnie CM, Hanson CE, Blaszczyk K, Inouye M, Ewels P, Ravindrarajah R, Keniry A, Hunt S, Carter M, Watkins N, Ouwehand W, Lewis CM, Cardon L, Lobo A, Forbes A, Sanderson J, Jewell DP, Mansfield JC, Deloukas P, Mathew CG, Parkes M, Satsangi J.Nat Genet. 2008 Jun;40(6):710-2. Epub 2008 Apr 27.
- 2.
- Genome-wide association scanning highlights two autophagy genes, ATG16L1 and IRGM, as being significantly associated with Crohn's disease.
Massey DC, Parkes M.Autophagy. 2007 Nov-Dec;3(6):649-51. Epub 2007 Sep 24.
- 3.
- Autophagy as a cell death and tumor suppressor mechanism.
Gozuacik D, Kimchi A.Oncogene. 2004 Apr 12;23(16):2891-906.
- Entrez GeneID:
- 345611
- Protein Accession#:
- AAI28169
- Gene Name:
- IRGM
- Gene Alias:
- IFI1,IRGM1,LRG-47,LRG47,MGC149263,MGC149264
- Gene Description:
- immunity-related GTPase family, M
- Omim ID:
- 608212
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Members of the p47 immunity-related GTPase (IRG) family, including IRGM, play an important role in the murine immune system; however, in humans this resistance system is greatly reduced. There is evidence that human IRGM plays a role in autophagy and control of intracellular mycobacteria (Bekpen et al., 2005; Singh et al., 2006 [PubMed 16888103]).[supplied by OMIM
- Other Designations:
- -
- Related Disease